Welcome to An Lab at Korea University

We are a computational genomics lab studying the etiology of developmental disorders and complex human diseases using high-dimensional genomic data. Our lab utilises a range of genomics and systems biology approaches to better understand regulatory features and cellular trajectory underlying disease development.

We focus on:

  • Understanding the genetic architecture of autism.
  • Leveraging whole genome sequencing (WGS) and single cell analyses to understand neurodevelopment and disorders.
  • Integrating multiomics data to better understand genetic heterogeneity in human disorders.

Technologies and methods

The An Lab is a computational biology research group specializing in advanced genomic analysis and AI-driven modeling. Our work focuses on long-read whole-genome sequencing, multi-omics integration, and cloud computing for large-scale data processing. We are also developing LLM-based deep learning models to enhance genomic data interpretation and analysis.

Collaborators

We work with closely with international collaborators, including the Sanders Lab at Oxford and the Werling lab at University of Wisconsin-Madison. Our team is a part of the Korean autism WGS consortium and closely collaborates with Prof. Hee Jeong Yoo at Seoul National University Bundang Hospital.

Joining An Lab

If you are interested in joining please go to the join us page.

Funding

We are grateful for funding from the National Research Foundation of Korea.

News

Aug 29th 2025

Huge congratulations to Ingyeong for being selected as NRF Graduate Fellowship recipients! 🎉

Aug 27th 2025

Chanhee successfully completed their Master's program. We wish much success in your next chapter!

Aug 20th 2025

Our new study developed the within-family standardized deviations (WFSD) method. The WFSD examined phenotypic deviation in autism (link).

Aug 16th 2025

Our new proteogenomic analysis reveals a distinct cancer subgroup with high IGF2BP expression (link).

Jun 26th 2025

Our latest review on autism genomic studies is now available (link).

Jun 4th 2025

We published a review on RNA-binding proteins and alternative splicing in Autism (link).

May 26th 2025

Excited to share our latest publication in Nature Communications, identifying novel genetic factors associated with Alzheimer’s disease and a cumulative effects model for risk liability (link).

Mar 7th 2025

We wrote a review on national biobank projects utilizing whole-genome sequencing for population-scale genomics (link).

Feb 18th 2025

Excited to share our latest paper on aberrant ERK signaling in astrocytes and its impact on learning and memory in RASopathy-associated BRAF mutant mouse models! (link).

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