An Lab· Korea University§ 01 · Research
Four threads, one question:
how does the genome shape the brain?
We work across deep learning, single-cell biology, large-scale sequencing, and integrative omics — bound by one question.
01 / 04
Deep Learning for Noncoding Genome
LLMs and deep learning for noncoding regulatory mutations in autism and neurodevelopmental disorders.
02 / 04
AI-Driven Virtual Cell
Large-scale scRNA-seq atlas + AI-driven virtual cell for risk gene discovery.
03 / 04
Genetic Architecture of Autism
Long-read WGS in one of the largest Korean cohorts — autism genetics in East Asian populations.
04 / 04
Integrative Multi-omics
Genomics, transcriptomics, proteomics — systems approaches to complex disorders.
§ 02 · News
Latest from the lab
Mar 30th 2026
Publication
Our review on genetic risk modeling approaches to resolve heterogeneity in psychiatric disorders is now published in Current Opinion in Genetics and Development.
Mar 24th 2026
Publication
Our new study on the co-occurrence of rare variants in autism is published in Genome Biology! We identified disrupted gene pairs in cytoskeletal pathways associated with increased severity in ASD.
Feb 25th 2026
Milestone
Congratulations to Dr. Yujin Kim and Dr. Soo-Whee Kim on completing their Ph.D.! We wish them all the best as they embark on their postdoctoral journey at the University of Oxford, UK.
Feb 5th 2026
Award
Congrats Ashish for the Best Poster Award and Nahyun for the Excellent Poster Award at the KOGO Winter Symposium 2026! 🎉
Jan 8th 2026
Award
Congratulations to Prof. Joon-Yong An for receiving the Korea University Alumni Association Academic Award (Health and Medical Sciences)! 🎉
Dec 24th 2025
Honor
We are grateful to share that Chaewon Min and Yeojin Ryu have been selected as recipients of graduate scholarships from the Cheongnyeong Rare Disease Research Foundation ((재)청녕희귀질환연구재단).
§ 03 · Selected Publications
Recent work
Genome Biology2026
Co-occurrence of rare variants implicates gene pairs in cytoskeletal pathways and is associated with increased severity in autism spectrum disorder
Lee H, Ko K, Kim S, Lee GH, Kim SW, Lee J, Song DY, Bong G, Han JH, Lee J, Kim YR, Lee Y, Kim E, Børglum AD, Grove J, Kim SH, Sun W, Yoo HJ, An JY
Genome Medicine2025
Evaluation of familial phenotype deviation to measure the impact of de novo mutations in autism
Kim SW, Lee H, Song DY, Lee GH, Han JH, Lee JW, Byun HJ, Son JH, Kim YR, Lee Y, Kim E, Werling DM, Kim SH, Sanders SJ, Yoo HJ, An JY
Nature Communications2025
Whole-genome sequencing analyses suggest novel genetic factors associated with Alzheimer's disease and a cumulative effects model for risk liability
Kim JP, Cho M, Kim C, Lee H, Jang B, Jung SH, Kim Y, Koh IG, Kim S, Shin D, Lee EH, Lee JY, Park Y, Jang H, Kim BH, Ham H, Kim B, Cho A, Raj T, Kim HJ, Na DL, Seo SW, An JY, Won HH
Genome Medicine2024
Whole genome sequencing analysis identifies sex differences of familial pattern contributing to phenotypic diversity in autism.
Kim SW, Lee HJ, Song DY, Lee GH, Ji JE, Park JW, Han JH, Lee JW, Byun HJ, Son JH, Kim YR, Lee YJ, Kim JW, Jung A, Lee JH, Kim EH, Kim SH, Lee JH, Satterstrom FK, Girirajan S, Børglum AD, Grove J, Kim EJ, Werling DM, Yoo HJ, An JY
Nature Communications2024
Proteogenomic analysis reveals non-small cell lung cancer subtypes predicting chromosome instability, and tumor microenvironment.
Song KJ, Choi SH, Kim KN, Hwang HS, Chang EH, Park JS, Shim SB, Choi SW, Heo YJ, An WJ, Yang DY, Cho KC, Ji WJ, Choi CM, Lee JC, Kim HR, Yoo JY, Ahn HS, Lee GH, Hwa CW, Kim SY, Kim KG, Kim MS, Paek EO, Na SJ, Jang SJ, An JY, Kim KP
§ 04 · Join us
We're looking for the
curious and the rigorous.
PhD students, postdocs, and undergraduate researchers — we’re looking for people drawn to AI-powered biology research.