An Lab· Korea University§ 01 · Research
Four threads, one question:
how does the genome shape the brain?
We work across deep learning, single-cell biology, large-scale sequencing, and integrative omics — bound by one question.
01 / 04
Deep Learning for Noncoding Genome
LLMs and deep learning for noncoding regulatory mutations in autism and neurodevelopmental disorders.
02 / 04
AI-Driven Virtual Cell
Large-scale multi-omics atlas + AI-driven virtual cell for AI drug discovery.
03 / 04
Genetic Architecture of Autism
Long-read WGS in one of the largest Korean cohorts — autism genetics in East Asian populations.
04 / 04
Integrative Multi-omics
Genomics, transcriptomics, proteomics — systems approaches to complex disorders.
§ 02 · News
Latest from the lab
May 31st 2026
Publication
Our new methods paper introducing AnnQ — a framework for quantifying cellular abnormality from reference-based single-cell annotation uncertainty — is now published in Briefings in Bioinformatics.
May 9th 2026
Publication
Our new study introducing IDAP — an integrated literature- and knowledge-graph-driven evidence prioritization pipeline for precision oncology — is now published in Bioinformatics.
Apr 27th 2026
Publication
Our review on tandem repeats in human brain evolution and disease susceptibility is now published in Molecules and Cells.
Apr 24th 2026
Publication
Our new study on region- and cell type-specific gene expression changes in the cerebellum after classical fear conditioning is now published in Communications Biology.
Mar 30th 2026
Publication
Our review on genetic risk modeling approaches to resolve heterogeneity in psychiatric disorders is now published in Current Opinion in Genetics and Development.
Mar 24th 2026
Publication
Our new study on the co-occurrence of rare variants in autism is published in Genome Biology! We identified disrupted gene pairs in cytoskeletal pathways associated with increased severity in ASD.
§ 03 · Selected Publications
Recent work
Briefings in Bioinformatics2026
AnnQ: reference-based quantification of cellular abnormality at single-cell resolution
Lee D, Byeon G, Chung S, Shin D, Park J, Koh I, An JY
Genome Biology2026
Co-occurrence of rare variants implicates gene pairs in cytoskeletal pathways and is associated with increased severity in autism spectrum disorder
Lee H, Ko K, Kim S, Lee GH, Kim SW, Lee J, Song DY, Bong G, Han JH, Lee J, Kim YR, Lee Y, Kim E, Børglum AD, Grove J, Kim SH, Sun W, Yoo HJ, An JY
Genome Medicine2025
Evaluation of familial phenotype deviation to measure the impact of de novo mutations in autism
Kim SW, Lee H, Song DY, Lee GH, Han JH, Lee JW, Byun HJ, Son JH, Kim YR, Lee Y, Kim E, Werling DM, Kim SH, Sanders SJ, Yoo HJ, An JY
Nature Communications2025
Whole-genome sequencing analyses suggest novel genetic factors associated with Alzheimer's disease and a cumulative effects model for risk liability
Kim JP, Cho M, Kim C, Lee H, Jang B, Jung SH, Kim Y, Koh IG, Kim S, Shin D, Lee EH, Lee JY, Park Y, Jang H, Kim BH, Ham H, Kim B, Cho A, Raj T, Kim HJ, Na DL, Seo SW, An JY, Won HH
Genome Medicine2024
Whole genome sequencing analysis identifies sex differences of familial pattern contributing to phenotypic diversity in autism.
Kim SW, Lee HJ, Song DY, Lee GH, Ji JE, Park JW, Han JH, Lee JW, Byun HJ, Son JH, Kim YR, Lee YJ, Kim JW, Jung A, Lee JH, Kim EH, Kim SH, Lee JH, Satterstrom FK, Girirajan S, Børglum AD, Grove J, Kim EJ, Werling DM, Yoo HJ, An JY
§ 04 · Join us
We're looking for the
curious and the rigorous.
PhD students, postdocs, and undergraduate researchers — we’re looking for people drawn to AI-powered biology research.