
Korean Autism Research Consortium (K-ARC)
The Korean Autism Research Consortium (K-ARC) is a collaborative initiative led by Dr. Hee Jeong Yoo at Seoul National University Bundang Hospital, bringing together leading researchers to advance autism spectrum disorder research through comprehensive genomic and multi-omics approaches. The consortium includes Dr. Eunjoon Kim (Synaptic Brain Dysfunctions, Institute for Basic Science), who provided early large seed funding for genomic resources. Dr. Joon-Yong An (Korea University) leads genomics analysis of whole-genome sequencing data.
Clinicians Drs. So Hyun (Sophy) Kim (Korea University), Mi Ae Oh (Kyung Hee University), and Jae Hyun Han (Seoul National University Bundang Hospital) conduct clinical and behavioral assessment. Drs. Yong-Seok Lee (Seoul National University), Eunha Kim (Korea University) and Dae-Ki Lee (Ewha Womans University) conduct animal model studies. Drs. Jae Sang Kim (Ewha Womans University), Woong Sun (Korea University) and Ji Yeon Lee (Seoul National University) conduct organoid research. Additional collaborators include Drs. Ilbin Kim (Gangnam CHA Hospital), Min-Sik Kim (DGIST), Jun Kim (Chungnam National University), Hong-Hee Won (Sungkyunkwan University), Woo-Jae Myung (Seoul National University Bundang Hospital), and Minji Jeon (Korea University) for genomics/multiomics analysis and AI model development.
Cohort & Key Findings
K-ARC has established one of the largest autism whole-genome sequencing cohorts of East Asian ancestry, with over 1,000 Korean families, enabling discoveries in genetic architecture underlying Korean ASD families.
Key Publications
Kim et al. 2025, Genome Medicine
Within-family analysis: de novo PTV and missense variants show stronger phenotypic effects accounting for familial background.
Kim et al. 2024, Genome Medicine
Sex differences and familial patterns contributing to phenotypic diversity in autism.
Kim et al. 2024, Briefings in Bioinformatics
CWAS-Plus: identifying noncoding variant associations.
Kim et al. 2024, Psychiatry and Clinical Neurosciences
Short tandem repeat expansions in East Asian ASD cases.
International Collaborations
- Stephan Sanders - University of Oxford
- Donna Werling - University of Wisconsin-Madison
- Brett Trost & Stephen Scherer - SickKids Hospital
- Anders D. Børglum & Jakob Grove - iPSYCH, Aarhus University, Denmark