Seoyeon is interested in leveraging single-cell data and bioinformatics to explore the molecular basis of human neurodevelopment and neurological disorders. To this end, she collaborates with experts in proteomics, transcriptomics, and epigenomics, applying her computational expertise and passion for neuroscience.

During her training, Seoyeon initiated the multi-omics analyses to decipher the impact of valproic acid on fetal ASD, revealing RNF146-driven dysregulation of the Wnt/beta-catenin pathway (Park et al., 2023). Building on this, she constructed a single-cell transcriptome atlas of the human brain, mapping disorder-risk gene dynamics from 7 gestational weeks to 90 years and identifying a perinatal surge in autism-associated genes within neural progenitors (Kim et al., 2024).

Seoyeon collaborates across disciplines to advance research on neurodevelopment and neurological disorders. As a visiting researcher at Columbia University, she conducted single-cell transcriptomic analyses in Alzheimer’s disease using the ROSMAP cohort and trained lab members in bioinformatics workflows. She is currently exploring how genetic and environmental factors interact to shape brain development, aiming to uncover key principles underlying neurological disorders.

Education & Training

• 2022-2024 M.Sc., Department of Integrated Biomedical and Life Science, Korea University
• 2018-2022 B.Sc., Biosystem and Biomedical Sciences, Korea University

Publication

• Kim S✻, Lee J✻, Koh IG, Ji J, Kim HJ, Kim E, Park J, Park JE, An JY†, An integrative single-cell atlas to explore the cellular and temporal specificity of neurological disorder genes during human brain development, Experimental & Molecular Medicine, 2024
• Park G✻, Jang WE✻, Kim S✻, Gonzales EL, Ji J, Choi S, Kim YJ, Park JH, Mohammad HB, Bang G, Kang M, Kim SB, Jeon SJ, Kim JY, Kim KP, Shin CY†, An JY†, Kim MS†, Lee YS†, Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder, Experimental and Molecular Medicine, 2023
• Kang M✻, Choi J, Han J, Araki T, Kim SW, Ryu HH, Kim MG, Kim S, Jang H, Kim SY, Hwang KD, Kim S, Yoo M, Lee J, Kim K, Park P, Choi JE, Han DH, Kim Y, Kim J, Chang S, Kaang BK, Ko JM, Cheon KA, An JY, Kim SJ, Park H, Neel BG, Kim CH†, Lee YS†, Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis, The Journal of Clinical Investigation, 2025
• Jang D✻, Hwa C, Kim S, Oh J, Shin S, Lee SJ, Kim J, Lee SE, Yang Y, Kim D, Lee S, Jung HR, Oh Y, Kim K, Lee HS, An JY†, Cho SY†, RNA N6-methyladenosine-binding protein YTHDFs redundantly attenuate cancer immunity by downregulating IFN-gamma signaling in gastric cancer, Advanced Science, 2024
• Song KJ✻, Choi S✻, Kim K✻, Hwang HS✻, Chang E, Park JS, Shim SB, Choi S, Heo YJ, An WJ, Yang DY, Cho KC, Ji W, Choi CM, Lee JC, Kim HR, Yoo J, Ahn HS, Lee GH, Hwa C, Kim S, Kim KG, Kim MS, Paek E, Na S†, Jang SJ†, An JY†, Kim KP†, Proteogenomic Analysis of a Korean Cohort Reveals Lung Cancer Subtypes Predictive of Metastasis, Chromosome Instability, and Tumor Microenvironment, Nature Communications, 2024
• Park HR✻, Shiva A, Cummings P, Kim S, Kim S, Lee E, Leong A, Chowdhury S, Shawber C, Carvajal R, Thurston G, AN JY, Lund AW, Yang HW, Kim M†. Angiopoietin-2-dependent spatial vascular destabilization promotes T-cell exclusion and limits immunotherapy in melanoma, Cancer Research, 2023

Awards

• 2024 Best paper award, Annual Conference of Korean Society for Bioinformatics
• 2023 Research Poster Award, BK21 L-HOPE graduate symposium
• 2023 AOHUPO Best Posters Award, HUPO World Congress
• 2022 Outstanding Poster Award, Annual Conference of Korean Society for Bioinformatics
• 2022 Outstanding Poster Award, International Conference: Korean Society for Molecular and Cellular Biology